教員紹介

SDGsへの取り組み

最終学歴

徳島大学大学院薬科学教育部 創薬科学専攻 博士後期課程修了

取得学位

博士（薬学）徳島大学

所属学会

日本薬学会、有機合成化学協会、日本ケミカルバイオロジー学会

現在の専門分野

精密有機合成化学、生物活性分子化学

現在の研究課題

有機合成化学および創薬化学の発展に資する新規三次元分子構造の構築法の開発

主要研究業績

脱芳香族化反応を伴った新規分子変換反応の開発
生命現象を解明する新規有用化合物の創製
特異な構造をもつ天然有機化合物の全合成

最近の研究業績

1) Yokoe, H.*; Kiriyama, A.; Shimoda, M.; Nakajima, S.; Hashizume, Y.; Endo, Y.; Iwamoto, R.; Tsubuki, M.; Kanoh, N.* Cis-selective double spirocyclization via searomatization and isomerization under thermodynamic control. J. Org. Chem. 2023, 88, 1803–1814.
2) Huang, Y.; Yokoe, H.; Kaiho-Soma, A.; Takahashi, K.; Hirasawa, Y.; Morita, H.; Ohtake, F.; Kanoh, N.* Design, synthesis, and evaluation of trivalent PROTACs having a functionalization site with Controlled Orientation Bioconjugate Chem. 2022, 33, 142–151.
3) Tanaka, T.; Okuyama-Dobashi, K.; Yokoe, H.; Takahashi, K.; Wiriyasermkul, P.; Kasai, H.; Yamashita, A.; Maekawa, S.; Enomoto, N.; Ryo, A.; Nagamori, S.; Tsubuki, M.; Moriishi, K.* Inhibitory effect of a novel thiazolinedione derivative on hepatitis B virus entry Antivir. Res. 2021, 194, 105165.
4) Yokoe, H.*; Mizumura, Y.; Sugiyama, K.; Yan, K.; Hashizume, Y.; Endo, Y.; Yoshida, S.; Kiriyama, A.; Tsubuki, M.; Kanoh, N.* Rapid Access to sispirocyclic dcaffolds enabled by diastereoselective intramolecular double functionalization of benzene rings Chem. Asian J. 2020, 15, 4271–4274.
5) Imai, M.; Yokoe, H.; Tsubuki, M.; Takahashi, N.* Growth inhibition of human breast and prostate cancer cells by cinnamic acid derivatives and their mechanism of action Biol. Pharm. Bull. 2019, 42, 1134–1139.
6) Nugroho, A. E.; Hashimoto, A.; Wong, C.-P.; Yokoe, H.; Tsubuki, M.; Kaneda, T.; Hadi, A. H. A.; Morita, H.* Ceramicines M–P from Chisocheton ceramicus: isolation and structure–activity relationship study J. Nat. Med. 2018, 72, 64–72.
7) Amano, R.; Yamashita, A.; Kasai, H.; Hori, T.; Miyasato, S.; Saito, S.; Yokoe, H.; Takahashi, K.; Tanaka, T.; Otoguro, T.; Maekawa, S.; Enomoto, N.; Tsubuki, M.; Moriishi, K.* Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress Antivir. Res. 2017, 145, 123–130.
8) Kasai, H.; Kawakami, K.; Yokoe, H.; Yoshimura, K.; Matsuda, M.; Yasumoto, J.; Maekawa, S.；Yamashita, A.; Tanaka, T.; Ikeda, M.; Kato, N.; Okamoto, T.; Matsuura, Y.; Sakamoto, N.; nomoto, N.; Takeda, S.; Fujii, H.; Tsubuki, M.; Kusunoki, M.; Moriishi, K.* Involvement of FKBP6 in hepatitis C virus replication Sci. Rep. 2015, 5, 16699.
9) Imai, M.; Kumaoka, T.; Hosokawa, M.; Sato, Y.; Li, C.; Sudoh, M.; Tamada, Y.; Yokoe H.; Saito, S.; Tsubuki, M.; Takahashi, N.* Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation Bioorg. Med. Chem. 2015, 23, 3788–3795.
10) Fujioka, K.; Yokoe, H.*; Inoue, A.; Soga, K.; Tsubuki, M.; Shishido, K.* Enantioselective synthesis of (+)-penostatin E J. Org. Chem. 2014, 79, 7512–7519.
11) Manabe, Y.; Kanematsu, M.; Yokoe, H.; Yoshida, M.; Shishido, K.* Concise total synthesis of heliannuols B and D Tetrahedron 2014, 70, 742–748.
12) Obase, A.; Kageyama, A.; Manabe, Y.; Ozawa, T.; Araki, T.; Yokoe H.; Kanematsu, M.; Yoshida, M.; Shishido, K.* Enantioselective total synthesis of pigmaeocins B and C Org. Lett. 2013, 15, 3666–3669.
13) Araki, T.; Manabe, Y.; Fujioka, K.; Yokoe, H.; Kanematsu, M.; Yoshida, M.; Shishido, K.* Total synthesis of (±)-folicanthine and (±)-chimonathine via a double intramolecular carbamoylketene-alkene [2+2] cycloaddition Tetrahedron Lett. 2013, 54, 1012–1014.
14) Araki, T.; Ozawa, T.; Yokoe, H.; Kanematsu, M.; Yoshida, M.; Shishido, K.* Diastereoselective Intramolecular carbamoyl ketene/alkene [2+2] cycloaddition: Enantioselective access to pyrrolidinoindoline alkaloids, Org. Lett. 2013, 15, 200–203.
15) Shen, H.; Yamashita, M.; Nakakoshi, M.; Yokoe, H.; Sudo, M.; Kasai, H.; Tanaka, T.; Fujimoto, Y.; Ikeda, M.; Kato, N.; Sakamoto, N.; Shindo, H.; Maekawa, S.; Enomoto, N.; Tsubuki, M.; Moriishi, K.* Inhibitory effects of caffeic acid and phenethyl ester derivatives on replication of hepatitis C virus PLOS ONE 2013, 8, e82299.
16) Ozawa, T.; Kanematsu, M.; Yokoe, H.; Yoshida, M.; Shishido, K.* Synthesis of (±)-esermethole via an intramolecular carbamoylketene-alkene [2+2] cycloaddition Heterocycles 2012, 85, 2927–2932.
17) Ozawa, T.; Kanematsu, M.; Yokoe, H.; Yoshida, M.; Shishido, K.* Total synthesis of debromoflustramines B and E based on the intramolecular carbamoylketene-alkene [2+2] cycloaddition J. Org. Chem. 2012, 77, 9240–9249.
18) Miyawaki, A.; Kikuchi, D.; Niki, M.; Manabe, Y.; Kanematsu, M.; Yokoe, H.; Yoshida, M.; Shishido, K.* Total synthesis of natural enantiomers of heliespirones A and C via the diastereoselective intramolecular Hosomi–Sakurai reaction J. Org. Chem. 2012, 77, 8231–8243.
19) Yokoe, H.*; Noboru, K.; Manabe, Y.; Yoshida, M.; Shibata, H.; Shishido, K.* Enantioselective synthesis of 8-epi-xanthatin and biological evaluation of xanthanolides and their derivatives Chem. Pharm. Bull. 2012, 60, 1340–1342.
20) Fujioka, K.; Yokoe, H.; Yoshida, M.; Shishido, K.* Total synthesis of penostatin B Org. Lett. 2012, 14, 244–247.
21) Yokoe, H.; Mitsuhashi, C.; Matsuoka, Y.; Yoshimura, T.; Yoshida, M.; Shishido, K.* Enantiocontrolled total syntheses of breviones A, B and C J. Am. Chem. Soc. 2011, 133, 8854–8857.
22) Sasaki, H.; Yokoe, H.; Shindo, M.; Yoshida, M.; Shishido, K.* Synthesis of Sundiversifolide and diversidolide via a diastereoselective [3+2] nitrile oxide cycloaddition reaction Heterocycles 2009, 77, 773–777.
23) Matsuo, K.; Yokoe, H.; Shishido, K.; Shindo, M.* Synthesis of diversifolide and structure revision Tetrahedron Lett. 2008, 49, 4279–4281.
24) Yokoe, H.; Yoshida, M.; Shishido, K.* Total synthesis of (–)-xanthatin Tetrahedron Lett. 2008, 49, 3504–3506.
25) Yokoe, H.; Sasaki, H.; Yoshimura, T.; Shindo, M.; Yoshida, M.; Shishido, K.* Total Synthesis of (+)-Sundiversifolide Org. Lett. 2007, 9, 969–971.

受賞

星薬科大学 大谷記念研究助成金（研究奨励金）/
新規多剤耐性克服作用化合物の創出を志向した高歪多環アルカロイドの全合成研究 星薬科大学紀要 2018, 60, 75–83.