教員紹介

SDGsへの取り組み

最終学歴

明治薬科大学大学院　薬学研究科　博士課程

取得学位

博士（薬学）

所属学会

日本生化学会、日本血栓止血学会、日本免疫学会、日本結晶学会

現在の専門分野

●モデリング・シミュレーション及びその応用
●循環器系に関わる因子と薬物の相互作用
●X線結晶構造解析

現在の研究課題

●血液凝固系におけるMgイオンの役割の解明
●新規生物活性を有するタンパクの探索とその構造の決定

主要研究業績

●血液凝固系におけるMgイオンの役割の解明
●タンパクの機能解析および構造解析

最近の研究業績

1. Chen H, Wei T, Saotome A, Sakaguchi K, Shikamoto Y, Mizuno H, Akita F, Shimizu T, Uehara-Ichiki T, Omura T. Aggregation ability of virus-specific antibodies is correlated with their capacity to neutralize Rice dwarf virus. (2012) JARQ. 46(1): 65-71.

2. Gopinath SC, Shikamoto Y, Mizuno H, Kumar PK. Snake-venom-derived Factor IX-binding protein specifically blocks the gamma-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X. (2007) Biochem. J. 405(2):351-7.

3. Gopinath SC, Shikamoto Y, Mizuno H, Kumar PK. A potent anti-coagulant RNA aptamer inhibits blood coagulation by specifically blocking the extrinsic clotting pathway. (2006) Thromb. Haemost. 95(5):767-71.

4. Nakagawa T, Shikamoto Y, Mizuno H, Murase T, Ishii H, Nakabayashi T, Ieko M, Mizukami K, Naitoh S, Takeda M, Tarumi T, Kaneko H. Molecular dynamics calculations of wild type vs. mutant protein C: relationship between binding affinity to endothelial cell protein C receptor and hereditary disease. (2006) J. Biomol. Struct. Dyn. 24(3):203-7.

5. Suzuki N, Shikamoto Y, Fujimoto Z, Morita T, Mizuno H. Crystallization and preliminary X-ray analysis of coagulation factor IX-binding protein from habu snake venom at pH 6.5 and 4.6.

6. Nakabayashi T, Mizukami K, Naitoh S, Takeda M, Shikamoto Y, Nakagawa T, Kaneko H, Tarumi T, Mizoguchi I, Mizuno H, Ieko M, Koike T. Protein C Sapporo (protein C Glu 25 --> Lys): a heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor. (2005) Thromb Haemost. 94(5):942-50.

7. Shikamoto Y, Suto K, Yamazaki Y, Morita T, Mizuno H. Crystal structure of a CRISP family Ca2+-channel blocker derived from snake venom. (2005) J. Mol.Biol. 350(4): 735-43.

8. Mizuguchi H, Yamazaki Y, Shikamoto Y, Shin Y, Sonoda J, Morita T. Prothrombin activation during carbon tetrachloride-induced acute liver injury in mice. (2003) Thromb. Res. 106(4-5):257-61.

9. Maita N, Nishio K, Nishimoto E, Matsui T, Shikamoto Y, Morita T, Sadler JE, Mizuno H. Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins. (2003) J. Biol. Chem. 278(39):37777-81.

10. Masuda H, Takenaka Y, Shikamoto Y, Kagawa M, Mizuno H, Tsuji FI.
Chromatography of isoforms of recombinant apoaequorin and method for the preparation of aequorin. (2003) Protein Expr. Purif. 31(2):181-7.

11. Shikamoto Y, Morita T, Fujimoto Z, Mizuno H.
Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein. (2003) J. Biol. Chem. 278(26):24090-4.

12. Arai T, Ikeda K, Akiyama H, Shikamoto Y, Tsuchiya K, Yagishita S, Beach T, Rogers J, Schwab C, McGeer PL. Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients witPick's disease, corticobasal degeneration and progressive supranuclear palsy. (2001) Acta Neuropathol. (Berl) 101(2):167-73.