教員紹介

SDGsへの取り組み

最終学歴

北里大学大学院薬学研究科修士課程

取得学位

薬学博士(北里大学)

所属学会

日本アレルギー学会、日本薬学会

現在の専門分野

免疫学

現在の研究課題

●マスト細胞の脱顆粒に関する研究

主要研究業績

1. Kaneko M., Kanesaka M., Yoneyama M., Tominaga T., Jirillo E., Kumazawa Y. Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation. Immunopharmacol. Immunotoxicol. 32(3): 454-461, 2010.

2. Kaneko M., Takimoto H., Sugiyama T., Seki Y., Kawaguchi K., Kumazawa Y. Suppressive effects of the flavonoids quercetin and luteolin on the accumulation of lipid rafts after signal transduction via receptors. Immunopharmacol. Immunotoxicol. 30(4):867-882, 2008.

3. Kaneko M., Akiyama Y., Takimoto H., Kumazawa Y. Mechanism of up-regulation of immunoglobulin A production in the intestine of mice unresponsive to lipopolysaccharide. Immunology 116(1):64-70, 2005.

最近の研究業績

1．Kaneko M., Iizuka T. and Nakajima T. Inhibition effect of Eucommia ulmoides leaf extract on interleukin 8 production by A549 cells. Biol. Pharm. Bull. 44(12): 1891-1893, 2021.

2．Kawaguchi K., Kaneko M., Miyake R., Takimoto H. and Kumazawa Y. Potent inhibitory effects of quercetin on inflammatory responses of collagen-induced arthritis in mice. Endocr. Metab. Immune Disord. Drug Targets. 19(3): 308-315, 2019.

3．Kaneko M. and Yamada A. Dynamics of plasma and granule membrane in murine bone marrow-derived mast cells after re-stimulation. Open Allergy J. 8 : 14-22, 2015.

4．Kubota M., Takimoto H., Kaneko M., Inoue J., Kumazawa Y. Potentiation of murine innate immunity by α-galacturonosyl-type glycosphingolipids isolated from Sphingomonas yanoikuyae and S. terrae. Immunopharmacol. Immunotoxicol. 31(3): 363-369, 2009.

5．Taimoto H., Kato H., Kaneko M., Kumazawa Y. Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts. Immunopharmacol. Immunotoxicol. 30(4):747-760, 2008.

6．Sugiyama T., Kawaguchi K., Dobashi H., Miyake R., Kaneko M., Kumazawa Y. Quercetin but not luteolin suppresses the induction of lethal shock upon infection of mice with Salmonella typhimurium. FEMS Immunol. Med. Microbiol. 53(3):306-313, 2008.

7．Kaneko M., Mizunuma T., Takimoto H., Kumazawa Y. Development of TCRαβ CD8αα intestinal intraepithelial lymphocytes in promoted by interleukin-15-producing cells constitutively stimulated by Gram-negative bacteria via TLR4. Biol. Pharm. Bull. 27(6):883-889, 2004.

8．Kaneko M., Kawakita T., Yamaoka Y., Nomoto K. Development of the susceptibility to oral tolerance induction in infant mice administered a herbal drug, Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang). Int. Immunopharmacol. 1(2):219-227, 2001.

9．Yamaguchi T., Maekawa T., Nishikawa Y., Nojima H., Kaneko M., Kawakita T., Miyamoto T., Kuraishi Y. Characterization of itch-associated response of NC mice with mite-induced chronic dermatitis. J. Dermatol. Sci. 25(1):20-28, 2001.

著書及び総説

金子正裕,熊沢義雄(分担執筆) XI各種生物の生体防御—微生物,植物,動物— 48.魚類の自然免疫関連遺伝子 生体防御医学事典 監修:鈴木和男 東京 朝倉書店 p.247-252. 2007.