弓田 長彦
Yumita Nagahiko
臨床薬学科／薬物動態学研究室（教授）
最終学歴
東邦大学大学院薬学研究科博士前期課程修了
取得学位
薬学博士（東邦大学）
所属学会
日本薬物動態学会、日本薬学会、日本癌学会、日本超音波医学会、日本癌治療学会
現在の専門分野
薬物動態学、生物薬剤学、超音波医学
現在の研究課題
●音響化学活性を有するナノ粒子を利用したがん治療方法の開発
●音響化学療法および光化学療法によるアポトーシス誘導の研究
●薬物の光毒性および音響毒性の薬物動態学的アプローチ
主要研究業績
●超音波による薬物の抗腫瘍活性化
●超音波増感剤の体内動態の研究
最近の研究業績
1. Yumita N, Iwase Y, Imaizumi T, Sakurazawa A, Kaya Y, Nishi K, Ikeda T, Umemura S, Chen F, Momose Y Sonodynamically Induced Anticancer Effects by Functionalized fullerenes Anticancer Res. 2013; 33:700-6, 2013
2. Yumita N, Iwase Y, Nishi K, Komatsu H, Fukai T, Ikeda T, Umemura S, Momose Y. Involvement of Reactive Oxygen Species in Sonodynamically Induced Apoptosis by Novel Porphyrin Derivative, DCPH-P-Na(I). Theranostics, 2, 880-888, 2012.
3. Yumita N, Iwase Y, Nishi K, Ikeda K, Onodera K, Fukai T, Umemura S, Momose Y. Apoptosis of HL-60 Cells Induced by Sonodynamic Therapy with Zinc Phthalocyanine Tetrasulfonate. Pharmacometrics, 82, 75-83, 2012
4. Yumita N, Iwase Y, Nishi K, Ikeda T, Fukai T, Onodera K, Takeda K, Umemura S, Okudaira K, Momose Y. Involvement of Reactive Oxygen Species in Sonodynamically Induced Apoptosis by 4-formyloximeetylidene-3-hydroxyl-2-vinyl-deuterio-Porphynyl (IX)-6-7-diaspartic acid (ATX-S10). Biochemistry & Analytical Biochemistry S2, 2-7, 2012.
5. Yumita N, Iwase Y, Nishi K, Ikeda T, Komatsu H, Fukai T, Onodera K, Nishi H, Takeda K, Umemura S, Okudaira K, Momose Y. Sonodynamically-induced antitumor effect of mono-l-aspartyl chlorin e6 (NPe6). Anticancer Res. 2011; 31:501-6.
6. Yumita N, Iwase Y, Onodera K, Nishi H, Takeda K,. Fukai, T, Umemura S, Okudaira K, Momose Y, Sonodynamic Antitumor Effect of Zinc Phthalocyanine Tetrasulfate on Murine Solid Tumor colon 26, Pharmacometrics, 2011; 80: 13-20.
7. N. Yumita, Y. Iwase, K. Nishi, T. Ikeda, S. Umemura, I. Sakata, Y Momose sonodynamicallyInduced Cell Damage and Membrane Lipid Peroxidation by Novel Porphyrin Derivative, DCPH-P-Na(I). Anticancer Res, 30, 2241-2246, 2010.
8. N. Sugita, Y.Iwase, N. Yumita, T. Ikeda, S.Umemura, Sonodynamically Induced Cell Damage by Rose Bengal Derivative, Anticancer Res,30, 3361-3366, 2010.
9. N. Yumita, K. Okudaira, Y Momose、S. Umemura: Sonodynamically Induced apoptosis and active oxygen generation by ATX-70, Cancer Chemother Pharmacol, 66，1078-1076, 2010.
10. K. Nishi, N. Fukunaga, T. Ono, T. Akuta, N. Yumita H. Watanabe, D. Kadowaki A. Suenaga, T. Maruyama, M. Otagiri, Construction of an Expression System for Human a1-Acid Glycoprotein in E. coli: the Roles of Oligosaccharide Moieties in Structural and Functional Properties, Drug Metab. Pharmacokinet. 25: 200?207, 2010.
11. N. Yumita, Q. S. Han, I. Kitazumi, S. Umemura: Sonodynamically Induced apoptosis, necrosis, and active oxygen generation by mono-l-aspartyl chlorin e6. Cancer Science 99,166-72, 2008.
12. N. Yumita, Q. S. Han, S. Umemura: Sonodynamically induced apoptosis with Porfimer Sodium in HL-60 cells. Anticancer Drugs 18, 1149-1156, 2007.
13. N. Yumita, N. Okuyama, K. Sasaki, S. Umemura: Sonodynamic therapy on chemically induced mammary tumor: pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of gallium-porphyrin complex ATX-70, Cancer Chemother Pharmacol, 60, 891-897, 2007.
14. Q. S. Han, N. Yumita, R Nishigaki: Involvement of caspase-3, 8 and 9 signaling pathways in the apoptosis of HL-60 cells induced by hyperthermia, Thermal Med, 23, 31-40, 2007.
15. N. Yumita, N. Okuyama, K. Sasaki, S.Umemura: Sonodynamic therapy on chemically induced mammary tumor: pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of porfimer sodium, Cancer Science. 95, 765-769, 2004.
16. K. Sasaki, K. Kawabata, N. Yumita, S. Umemura: Sonodynamic treatment of murine tumor through second-harmonic superimposition, Ultrasound Med & Biol, 30, 1233-1238, 2004.
17. N, Yumita, S. Umemura: Ultrasonically Induced Cell Damage and Membrane Lipid Peroxidation by Photofrin II: on the Mechanism of Sonodynamic Activation, J Med Ultrasonics. 31, 35-41, 2004.
18. N, Yumita, S. Umemura: Sonodynamic antitumour effect of chloroaluminum phthalocyanine tetrasulfonate on murine solid tumour., J. Pharm Pharmacol 56, 85-90, 2003.
19. N, Yumita, S. Umemura: Sonodynamic Therapy with Photofrin II on AH130 Solid Tumor: Pharmacokinetics, Tissue Distribution and Sonoodynamic Antitumoral Efficacy of Photofrin II, Cancer Chemother Pharmaco 51, 174-178, 2003.
20. N, Yumita, S. Umemura: Ultrasonically Induced cell damage and active oxygen generation by 4-formyloximeetylidene-3-hydroxyl-2-vinyl-deuterio- (ア) porphynyl(IX)-6-7-diaspartic acid (ATX-S10): on the mechanism of sonodynamic activation, Biochimica et Biophysica Acta. 1620, 179-184, 2003
21. N, Yumita, S. Umemura: Sonodynamically induced antitumor effect of eosin Y. Ultrasounics. 9, 259-265, 2002.
22. K. Sasaki, N. Yumita, R. Nishigaki, I. Sakata, S. Nakajima and S. Umemura: Pharmacokinetic study of gallium-porphyrin photo- and sono- sensitizer, ATX-70, in tumor-bearing mice. Jpn J Cancer Res. 92, 989-995, 2001.
23. N. Yumita, R. Nishigaki, S. Umemura: Sonodynamically induced antitumor effect of photofrin II on colon 26 carcinoma. Cancer Res. Clin. Oncol. 126, 601-606, 2000.
24. N. Yumita, S. Umemura, R. Nishigaki: Ultrasonically induced cell damage enhanced by photofrin II: mechanism of sonodynamic activation. In Vivo. 14 425-9, 2000.
25. ZH. Jin, N. Miyoshi, K. Ishiguro, S. Umemura, K. Kawabata, N. Yumita, I. Sakata, K Takaoka, T Udagawa, S. Nakajima, H Tajiri, K Ueda, M Fukuda, M Kumakiri: Combination effect of photodynamic and sonodynamic therapy on experimental skin squamous cell carcinoma in C3H/HeN mice. J Dermatol. 27, 294-306, 2000.
26. N. Yumita, R. Nishigaki, I. Sakata, S. Nakajima, S. Umemura: Sonodynamically induced antitumor effect of 4-formyloximethylidene-3-hydroxy-2-vinyl-deuterio-porphynyl(IX)-6,7-dia spartic acid (ATX-S10). Jpn J Cancer Res. 91, 255-60, 2000.
受賞
●1989年 日立製作所より戦略特許賞受賞
●1992年 科学技術庁長官賞（第51回注目発明選定証）受賞
●1992年 日本超音波医学会優秀論文賞として第6回菊池賞受賞
●2005年 日本超音波医学会優秀論文賞として第19回菊池賞受賞
