教員紹介

SDGsへの取り組み

最終学歴

千葉大学大学院医学薬学府修士課程 修了

取得学位

博士（薬科学）

所属学会

日本薬物動態学会、日本薬剤学会、日本薬学会

現在の専門分野

薬物動態学、生物薬剤学

現在の研究課題

●B細胞リンパ腫における薬物耐性亢進メカニズムの解明
●トランスポーターのがん組織特異的な機能調節因子の同定とがん治療への応用
●苦味刺激による薬物の体内動態変動とそのメカニズムの探索
●がん選択性の高いDrug Delivery Systemの創出に関する研究

主要研究業績

●薬物排出系トランスポーターの組織特異的な機能調節因子の同定
●薬物の苦味定量によるP-糖タンパク質の基質認識性予測
●がん転移時における薬物排出系トランスポーターの機能上昇とそのメカニズムの解析
●肝薬物代謝酵素の発現誘導および活性阻害評価における肝細胞３D培養系の有用性評価
●アルギン酸の新規有用性評価
●肝疾患時におけるトランスポーターの局在および発現量の変動

最近の研究業績

1. Yano K, Todokoro I, Kamioka H, Tomono T, Ogihara T. Functional Alterations of Multidrug Resistance-Associated Proteins 2 and 5, and Breast Cancer Resistance Protein upon Snail-Induced Epithelial-Mesenchymal Transition in HCC827 cells. Biol Pharm Bull. 2020 in press.

2. Mizoi K, Arakawa H, Yano K, Koyama S, Kojima H, Ogihara T. Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models. Biomedicines. 2020;8(10):374.

3. Arakawa H, Yamada H, Arai K, Kawanishi T, Nitta N, Shibata S, Matsumoto E, Yano K, Kato Y, Kumamoto T, Aoki I, Ogihara T. Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging. Int J Pharm. 2020;586:119575.

4. Kamioka H, Tomono T, Fujita A, Onozato R, Iijima M, Tsuchida S, Arai T, Fujita Y, Zhang X, Yano K, Ogihara T. Moesin-Mediated P-Glycoprotein Activation During Snail-Induced Epithelial-Mesenchymal Transition in Lung Cancer. J Pharm Sci. 2020;109(7):2302－2308.

5. Yano K, Okabe C, Fujii K, Kato Y, Ogihara T. Regulation of breast cancer resistance protein and P-glycoprotein by ezrin, radixin and moesin in lung, intestinal and renal cancer cell lines. J Pharm Pharmacol. 2020;72(4):575 – 582.

6. Yano K, Seto S, Kamioka H, Mizoi K, Ogihara T. Testosterone and androstenedione are endogenous substrates of P-glycoprotein. Biochem Biophys Res Commun. 2019;520(1):166 – 170.

7. Kasahara F, Kato T, Idota Y, Takahashi H, Kakinuma C, Yano K, Arakawa H, Hara K, Miyajima C, Ogihara T Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats. Biol Pharm Bull. 2019;42(3):365 – 372.

8. Idota Y, Kato T, Shiragami K, Koike M, Yokoyama A, Takahashi H, Yano K, Ogihara T. Mechanism of Suppression of Blood Glucose Level by Calcium Alginate in Rats. Biol Pharm Bull. 2018;41(9):1362 – 1366.

9. Kato T, Idota Y, Shiragami K, Koike M, Nishibori F, Tomokane M, Seki T, Itabashi K, Hakoda K, Takahashi H, Yano K, Kobayashi T, Obara N, Ogihara T. Randomized, Double-Blind, Crossover Clinical Trial of the Effect of Calcium Alginate in Noodles on Postprandial Blood Glucose Level. Biol Pharm Bull. 2018;41(9):1367 – 1371.

10. Morimoto K, Tominaga Y, Agatsuma Y, Miyamoto M, Kashiwagura S, Takahashi A, Sano Y, Yano K, Kakinuma C, Ogihara T, Tomita M. Intestinal secretion of indoxyl sulfate as a possible compensatory excretion pathway in chronic kidney disease. Biopharm Drug Dispos. 2018;39(7):328 – 334.

11. Koyama S, Arakawa H, Itoh M, Masuda N, Yano K, Kojima H, Ogihara T. Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates. Biopharm Drug Dispos. 2018;39(4):187 – 195.

12. Tomono T, Machida T, Kamioka H, Shibasaki Y, Yano K, Ogihara T. Entinostat reverses P-glycoprotein activation in snail-overexpressing adenocarcinoma HCC827 cells. PLoS One. 2018;13(7):e0200015.

13. Tomono T, Yano K, Ogihara T. Snail-Induced Epithelial-to-Mesenchymal Transition Enhances P-gp-Mediated Multidrug Resistance in HCC827 Cells. J Pharm Sci. 2017;106(9):2642 – 2649.

14. Yano K, Shimizu S, Tomono T, Ogihara T. Gastrointestinal Hormone Cholecystokinin Increases P-Glycoprotein Membrane Localization and Transport Activity in Caco-2 Cells. J Pharm Sci. 2017;106(9):2650 – 2656.

15. Ogihara T, Arakawa H, Jomura T, Idota Y, Koyama S, Yano K, Kojima H. Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity. J Toxicol Sci. 2017;42(4):499 – 507.

16. Arakawa H, Kamioka H, Jomura T, Koyama S, Idota Y, Yano K, Kojima H, Ogihara T. Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential. Biol Pharm Bull. 2017;40(7):967 – 974.

17. Yano K, Tomono T, Kanagawa M, Akiyama S, Ogihara T. Effect of Phosphate Binder on the Intestinal Absorption of Antihypertensive Drugs. J Community Pharm Pharm Sci. 2017;9(2):239 – 245.

18. Hashiba H, Yano K, Tomono T, Kanagawa M, Ogihara T. Comparative Studies in the Risk of Developing Long QT Syndrome by Antidepressive Agents. J Jpn Soc Hosp Pharm. 2017;52(9):1148-1152

19. Idota Y, Kogure Y, Kato T, Yano K, Arakawa H, Miyajima C, Kasahara F, Ogihara T. Relationship between Physical Parameters of Various Metal Ions and Binding Affinity for Alginate. Biol Pharm Bull. 2016;39(11):1893 – 1896.

20. Doi N, Akiyama S, Yano K, Takahashi E, Omi A, Idota Y. Ogihara T. Comparison of Brand-name and Generic Products of Latanoprost Ophthalmic Solution with Respect to the Sense of Use. Jpn. J. Pharm. Health Care Sci. 2016;42(9):651 – 658.

21. Tomono T, Kajita M, Yano K, Ogihara T. Adenovirus vector infection of non-small-cell lung cancer cells is a trigger for multi-drug resistance mediated by P-glycoprotein. Biochem Biophys Res Commun. 2016;476(4):183 – 187.

22. Yano K, Otsuka K, Kato Y, Kawabata H, Ohmori S, Arakawa H, Ogihara T. Different regulation of P-glycoprotein function between Caco-2 and Caki-1 cells by ezrin, radixin and moesin proteins. J Pharm Pharmacol. 2016;68(3):361 – 367.

23. Arakawa H, Kamioka H, Kanagawa M, Hatano Y, Idota Y, Yano K, Morimoto K, Ogihara T. Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs. Biopharm Drug Dispos. 2016;37(1):39 – 45.

24. Idota Y, Kogure Y, Kato T, Ogawa M, Kobayashi S, Kakinuma C, Yano K, Arakawa H, Miyajima C, Kasahara F, Ogihara T. Cholesterol-Lowering Effect of Calcium Alginate in Rats. Biol Pharm Bull. 2016;39(1):62 – 67.

25. Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T. Interaction of Peptide Transporter 1 With D-Glucose and L-Glutamic Acid; Possible Involvement of Taste Receptors. J Pharm Sci. 2016;105(1):339 – 342.

26. Tomono T, Otsuka K, Yano K, Kanagawa M, Arakawa H, Ogihara T. Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats. Biol Pharm Bull. 2015;38(12):1960 – 1963.

27. Tomono T, Yano K, Motegi T, Takimoto S, Hagiwara M, Idota Y, Kano T, Arakawa H, Morimoto K, Kakinuma C, Takahara A, Ogihara T. P-GLYCOPROTEIN PLAYS A KEY ROLE IN THE CONTRACTIONARY EFFECTS AGAINST BRAIN INFARCTION OF CILNIDIPINE. Drug Metab Rev. 2015;47:280.

28. Yano K, Mita S, Morimoto K, Haraguchi T, Arakawa H, Yoshida M, Yamashita F, Uchida T, Ogihara T. Multiple Linear Regression Analysis Indicates Association of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity, Measured with a Sensor. J Pharm Sci. 2015;104(9):2789 – 2794.

29. Yano K, Idota Y, Arakawa H, Inoue T, Ogihara T. A Comparative Examination of Two Pre-existing Tablets and One Double sized Tablet from the View of Both Recipient and Pharmacist. Jpn Pharmacol Ther. 2015;43:165 – 173.

30. Arakawa H, Saito S, Kanagawa M, Kamioka H, Yano K, Morimoto K, Ogihara T. Evaluation of a thiodipeptide, L-phenylalanyl-Ψ[CS-N]-L-alanine, as a novel probe for peptide transporter 1. Drug Metab Pharmacokinet. 2014;29(6):470 – 474.

31. Yano K, Takimoto S, Motegi T, Tomono T, Hagiwara M, Idota Y, Morimoto K, Takahara A, Ogihara T. Role of P-Glycoprotein in Regulating Cilnidipine Distribution to Intact and Ischemic Brain. Drug Metab Pharmacokinet. 2014;29(3):254 – 258.

32. Zhang P, Idota Y, Yano K, Negishi M, Kawabata H, Arakawa H, Morimoto K, Tsuji A, Ogihara T. Characterization of Cesium Uptake Mediated by a Potassium Transport System of Bacteria in a Soil Conditioner. Biol Pharm Bull. 2014;37(4):604 – 607.

33. Yano K, Tomono T, Sakai R, Kano T, Morimoto K, Kato Y, Ogihara T. Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo. J Pharm Sci. 2013;102(8):2875 – 2881.

34. Yano K, Sekine S, Nemoto K, Fuwa T, Horie T. The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat. Biochem Pharmacol. 2010;80(4):533 – 539.
Sekine S, Yano K, Saeki J, Hashimoto N, Fuwa T, Horie T. Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices. Biochem Biophys Res Commun. 2010;399(2):279 – 285.

著書及び総説

【総説】
Yano K, Tomono T, Ogihara T. Advances in Studies of P-Glycoprotein and Its Expression Regulators. Biol Pharm Bull. 2018;41(1):11 – 19.

【著書】
矢野　健太郎：ファルマシアTopics, 日本薬学会, 63(4):352-359, 2015