教員紹介

SDGsへの取り組み

最終学歴

北海道大学大学院　薬学科研究科　博士課程修了

取得学位

薬学博士

所属学会

SAM研究協議会、日本薬学会

現在の専門分野

分子薬理学、遺伝学、実験動物学

現在の研究課題

老化促進モデルマウスの老化機構と老人性疾患の治療に関する研究

主要研究業績

●老化促進モデル動物(SAMP8)の学習記憶障害発症機構解明の研究
●分子遺伝学的および統計遺伝学的手法によるSAMP8の学習記憶障害発症責任遺伝子の同定に関する研究
●多発性嚢胞腎症の発症機序解明と栄養学的治療に関する研究

最近の研究業績

1. Keiko Tonooka, Lynn Yoshida, Koji Tomobe, Yoko Kunisue, Masaru Terada,TatsuoShinozuka, Sensitive Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Determination of Risperidone, Olanzapine, Quetiapine, Clozapine, Ziprasidone, Perospirone, Aripiprazole and Blonanserin in Human Serum. Am. J. Anal. Chem., 2018, 9, 88-97

2. Kazuya Mori, Etienne Kochole Obossou, Shoutaro Suwa, Shogo Miura, Soon Oh, Natsuki Jinbo, Yukiko Ishibashi, Yasuo Shikamoto, Tetsuji Hosono, Takahiro Toda, Koji Tomobe, Tatsuo Shinozuka, Shigeo Nakajo. Human immunodeficiency virus type I (HIV-1) reverse transcriptase inhibitory effect of Cymbopogon Nardus essential oil. Int. J. Adv. Res. Botany, 2016, 2 (1), 1-8.

3. Tonooka Keiko, Naruki Nobuhiko, Honma Kou, Agei Kohei, Okutsu Mayumi, Hosono Tetsuji, Kunisue Yoko, Terada Masaru, Tomobe Koji, Shinozuka Tatsuo. Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of nine local anesthetic drugs. Forensic Science International, 2016, 265, 182-185

4. Miki Fujii, Chieri Hata, Munetada Ukita, Chie Fukushima, Chihiro Matsuura, Yoshie Kawashima-Ohya, Koji Tomobe and Tsuyoshi Kawashim. Characterization of a Thermostable 8-oxoguanine DNA Glycosylase Specific for GO:N Mismatches from the Thermoacidophilic Archaeon Thermoplasma volcanium. Archaea, 2016, 2016,1-10

5. Kota Makino, Runa Omachi, Hiroka Suzuki, Koji Tomobe, Tsuyoshi Kawashima, Toshiharu Nakajima, Yoshie Kawashima-Ohya. Apoptosis occurs during early development of the bursa of Fabricius in chicken embryos. Biol. Pharm. Bull. 2014; 37(12), 1982-1985.

6. Hikari Minoshima, Yu Ikeda, Miki Fujii, Mai Satoh, Tomoaki Ishikawa, Youichi Itoh, Yoshie Kawashima-Ohya, Koji Tomobe, Yoshiaki Omata, Tsuyoshi Kawashima. Specificity of Fur binding to the oxidative stress response gene promoter in the facultative anaerobic archaeon thermoplasma. Biol. Pharm. Bull. 2014; 37(3), 481-485.

7. Maruf Mohammad Akbor, Koji Tomobe, Tomomi Yamada, Juhyon Kim, Hiroki Mano, Nobuyuki Kurosawa, Kazuo Sasaki, Yasuyuki Nomura, Masaharu Isobe. Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice. BBRC 2013; 144, 25-30.

8. Koji Tomobe, Tatsuo Shinozuka, Tsuyoshi Kawashima, Yoshie Kawashima-Ohya, Yasuyuki Nomura. Age-related changes of forkhead transcription factor FOXO1 in the liver of senescence-accelerated mouse SAMP8. Arch. Gerontol. Geriatr. 2013; 57, 417-422.

9. Junichi Shirako, Marina Kawasaki, Kotoe Komine, Yoko Kunisue, Masaru Terada, Chizuko Sasaki, Wataru Irie, Chikako Murakami, Keiko Tonooka, Koji Tomobe, Tastuo Shinozuka. Simultaneous determination for oxicam non-steroidal anti-inflammatory drugs in human serum by liquid chromatography-tandem mass spectrometry. Foren. Sci. Int. 2013; 227, 100-102.

10. Yu Ikeda, Hikari Minoshima, Mai Satoh, Tomoaki Ishikawa, Yoshie Kawashima-Ohya, Koji Tomobe, Yoshiaki Omata, Tsiyoshi Kawashima. Transcriptional factor fur from thermoplasma volcanium binds its own promoter DNA in a divalent cation-dependent manner. J. Gener. Appl. Microbiol.2012; 58, 465-473.

11. K. Tomobe, T. Shinozuka, M. Kuroiwa, Y. Nomura. Age-related changes of Nrf2 and phosphorylated GSK-3β in a mouse model of accelerated aging (SAMP8). Arch. Gerontol. Geriatr. 2012; 54(2), e1-e7

12. K. Tomobe, Y. Nomura. Neurochemistry, Neuropathology, and Heredity in SAMP8: A Mouse Model of Senescence. Neurochem. Res. 2009; 34(4),660-669.

13. S. Kijimoto-Ochiai, T. Koda, T. Suwama, H. Matsukawa, M. Fujii, K. Tomobe, M. Nishimura. Low expression of Neu2 sialidase in the thymus of MS/J mice-existence of neuraminidase positive cells “Neu-medullocyte” in the murine thymus. Glycoconj. J. 2008; 25(8), 787-796.

14. Tomobe K, Fujii H, Sun B, Nishioka H, Aruoma O, Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol. Biomedicine and Pharmacothrapy, 2007; 61(7), 427-434.

15. Tomobe K, Okuma Y, Nomura Y., Impairment of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse (SAM) P8. Brain Res. 2007;1141:214-7.

16. Nishimura H, Higuchi O, Tateshita K, Tomobe K, Okuma Y, Nomura Y., Antioxidative activity and ameliorative effects of memory impairment of sulfur-containing compounds in Allium species. Biofactors. 2006;26(2):135-46.

17. Tomobe K, Isobe M, Okuma Y, Kitamura K, Oketani Y, Nomura Y., Genetic analysis of learning and memory deficits in senescence-accelerated mouse (SAM). Physiol Behav. 2005;84(4):505-10.

18. Tanaka J, Okuma Y, Tomobe K, Nomura Y., The age-related degeneration of oligodendrocytes in the hippocampus of the senescence-accelerated mouse (SAM) P8: a quantitative immunohistochemical study. Biol Pharm Bull. 2005;28(4):615-8.

19. Kijimoto-Ochiai S, Doi N, Matsukawa H, Fujii M, Tomobe K., Localization of sialidase-positive cells expressing Mac-1 and immunoglobulin in the mouse thymus.
Glycoconj J. 2004;20(6):375-84. Erratum in: Glycoconj J. 2005;22(7-9):463.

20. Tomobe K, Philbrick DJ, Ogborn MR, Takahashi H, Holub BJ., Effect of dietary soy protein and genistein on disease progression in mice with polycystic kidney disease. Am J Kidney Dis. 1998;31(1):55-61.

21. Ogborn MR, Sareen S, Tomobe K, Takahashi H, Crocker JF, Renal tubule Na,K-ATPase polarity in different animal models of polycystic kidney disease. J Histochem Cytochem. 1995;43(8):785-90.

22. Aukema HM, Yamaguchi T, Tomobe K, Philbrick DJ, Chapkin RS, Takahashi H, Holub BJ., Diet and disease alter phosphoinositide composition and metabolism in murine polycystic kidneys. J Nutr. 1995;125(5):1183-91.

23. Tomobe K, Philbrick D, Aukema HM, Clark WF, Ogborn MR, Parbtani A, Takahashi H, Holub BJ, Early dietary protein restriction slows disease progression and lengthens survival in mice with polycystic kidney disease. J Am Soc Nephrol. 1994;5(6):1355-60.

24. Aukema HM, Ogborn MR, Tomobe K, Takahashi H, Hibino T, Holub BJ, Effects of dietary protein restriction and oil type on the early progression of murine polycystic kidney disease. Kidney Int. 1992;42(4):837-42.

25. Aukema HM, Chapkin RS, Tomobe K, Takahashi H, Holub BJ., In vivo formation of polyphosphoinositide isomers and association with progression of murine polycystic kidney disease.
Exp Mol Pathol. 1992;57(1):39-46.